Related Experiment Videos
Obesity and renal transplantation
R M Merion1, A M Twork, L Rosenberg
1Department of Surgery, University of Michigan Medical School, Ann Arbor.
Surgery, Gynecology & Obstetrics
|May 1, 1991
Summary
Pre-existing obesity did not significantly impact renal transplant outcomes, with similar patient and graft survival rates. Obese recipients experienced more wound infections and greater weight gain post-transplant.
Area of Science:
- Nephrology
- Transplantation Surgery
- Obesity Medicine
Background:
- Pre-existing obesity is a common comorbidity in patients with end-stage renal disease.
- The impact of obesity on renal transplant outcomes requires further investigation.
Purpose of the Study:
- To evaluate the influence of pre-existing obesity on outcomes following renal transplantation.
- To identify potential risks and benefits associated with renal allografts in obese recipients.
Main Methods:
- A cohort study of 263 renal allograft recipients treated with cyclosporine.
- Patients were categorized as obese (pre-transplant weight >120% ideal body weight) or nonobese.
- Outcomes including complications, weight changes, and survival rates were compared between groups.
Main Results:
- Obese recipients (15%) showed a significantly higher incidence of wound infections (17.5% vs. 6.3%).
- Post-transplant weight gain was significantly higher in obese recipients (14.2 kg vs. 8.9 kg) during the first year.
- Patient survival (90.5% vs. 93%) and graft survival (64.5% vs. 71.8%) rates at three years were similar between obese and nonobese groups.
Conclusions:
- Obesity is not a major risk factor for renal transplantation, with comparable long-term patient and graft survival.
- Increased wound infection rates and post-transplant weight gain are notable adverse outcomes in obese renal transplant recipients.
- Obese patients with end-stage renal disease are suitable candidates for renal transplantation.