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[Multiple malignomas--an analysis of 352 patients].

T Feyerabend¹, E Richter, A Brandt

¹Klinik und Poliklinik für Strahlentherapie, Universität Würzburg.

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [Et Al]

|April 1, 1991

Summary

This study analyzed multiple primary malignant tumors in irradiated patients. While multiple tumors occurred, the data did not suggest an elevated risk for radiation-induced malignancies.

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Area of Science:

Oncology
Radiation Oncology
Epidemiology

Background:

Multiple primary malignant tumors (MPMTs) are a concern in cancer survivors.
Understanding the incidence and characteristics of MPMTs after radiotherapy is crucial.

Purpose of the Study:

To investigate the occurrence and patterns of multiple primary malignant tumors in patients treated with radiotherapy.
To assess the potential association between radiotherapy and the development of secondary malignancies.

Main Methods:

Retrospective analysis of patient records from a radiotherapy department.
Inclusion of data from two distinct time periods (1958-1976 and 1977-1988).
Calculation of incidence rates and analysis of tumor characteristics and patient demographics.

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Main Results:

Out of 8234 patients irradiated between 1977-1988, 2.56% developed MPMTs.
A total of 352 patients had MPMTs, with varying numbers of tumors per patient.
The mean interval for a second primary tumor was 5.7 years.
18 patients developed a second malignancy in a previously irradiated area.
No elevated risk for radiation-induced malignancies was indicated by the clinic's data.

Conclusions:

The study observed a certain incidence of multiple primary malignant tumors in irradiated patients.
Analysis of intervals between tumors and location of secondary malignancies was performed.
The findings suggest that the clinic's data do not support an increased risk of radiation-induced malignancies.