[Cytotoxicity of lipid ether ilmofosine in combination with radiotherapy in vitro]

Alkyllysophospholipids (ALP) represent a new class of cytotoxic agents. The cytotoxic potential was demonstrated by in vivo and in vitro models. In this study the interaction of the ALP Ilmofosine in combination with radiotherapy was tested in vitro using the colony forming assay. The cell lines B-16, K-562 and Meth-A were used as targets. The cell lines showed similar sensitivity to radiation therapy. The B-16 cell line proved to be resistant to Ilmofosine; the K-562 cell line showed little sensitivity whereas the Meth-A cell line was very sensitive to Ilmofosine. In the K-562 and Meth-A cell lines that were sensitive to both agents a clear addition of both effects was observed. In the case of the B-16 cell line in combination no effect was seen exceeding the pure radiation effect. No synergistic and no antagonistic effect was observed.