[Peptide inhibitors of coagulative transformation of fibrinogen]

The human blood plasma has peptide inhibitors of fibrinogen coagulative transformation that differ in molecular weight. Amino acid composition and N-terminal amino acid sequence of the largest peptide show that it precedes the lighter ones. The blood plasma of white rats and a bull contains inhibitors being alike in the action upon hemostasis and in amino acidic composition. As shown in investigations of white rats, up to 97% of pulled peptides, inhibitors of fibrinogen coagulative transformation is deposited in the viscera tissues. The mobile mechanism of the inhibitor redistribution in blood and tissue proves their great role in blood stabilization. The inhibitors of the peptide nature are believed to supply basic antipolymerisation plasma activity preventing fibrinogen formation in constant blood coagulation with slow intensity.