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Deferred therapy in well and moderately differentiated prostate cancer
1Department of Urology, Karolinska Hospital, Stockholm, Sweden.
Acta Oncologica (Stockholm, Sweden)
|January 1, 1991
Summary
Surveillance for localized prostate cancer shows a 20% risk of metastases and 15% risk of prostate cancer death within 10 years. These outcomes are similar to those seen after radical prostatectomy and radiation therapy.
Area of Science:
- Oncology
- Urology
- Cancer Research
Background:
- Localized prostate cancer management involves active surveillance, radical prostatectomy, and radiation therapy.
- Long-term outcomes data are crucial for treatment decision-making in prostate cancer.
Purpose of the Study:
- To evaluate the 10-year risk of metastases and prostate cancer-specific mortality in patients with localized prostate cancer managed with surveillance.
- To compare surveillance outcomes with established results from radical treatments.
Main Methods:
- A surveillance study including 122 patients diagnosed with localized prostate cancer.
- 10-year follow-up to assess the incidence of metastases and death due to prostate cancer.
Main Results:
- After 10 years, 20% of patients developed metastases.
- The risk of dying from prostate cancer within 10 years was 15% for the studied cohort.
- These rates are comparable to long-term follow-up data from radical prostatectomy and radiation therapy.
Conclusions:
- Active surveillance for localized prostate cancer yields long-term outcomes comparable to radical treatment options.
- These findings support surveillance as a viable management strategy for select patients with localized prostate cancer.
- Further research may refine patient selection for active surveillance to optimize oncological outcomes.