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Updated: Jun 14, 2026

09:58
Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
About the catalytic reduction of the carboxyl group of aliphatic acids
Helvetica Chimica Acta
|March 19, 2010
Abstract
No abstract available in PubMed .
Keywords:
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Although it is possible to reduce a carboxylic acid to an aldehyde, strong reducing agents, like lithium aluminum hydride (LAH), prohibit a controlled reduction, instead causing the generated aldehyde to instantly over-reduce to a primary alcohol.
Reducing carboxylic acid derivatives like acyl chlorides (RCOCl), esters (RCO2R′), and nitriles (RCN) using milder aluminum hydride agents like lithium tri-tert-butoxyaluminum hydride [LiAlH(O-t-Bu)3] and diisobutylaluminum hydride [DIBAL-H] allows...
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