Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Screening for prostatic cancer. Investigational models.

P Iversen1, S T Torp-Pedersen

  • 1Department of Urology, Herlev Hospital, University of Copenhagen, Denmark.

Acta Oncologica (Stockholm, Sweden)
|January 1, 1991
PubMed
Summary

Prostate cancer screening shows promise due to its long preclinical phase. However, its uncertain epidemiology questions the true benefit of screening programs, necessitating large trials to confirm effects on mortality and morbidity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NfL and GFAP in serum are associated with microstructural brain damage in progressive multiple sclerosis.

Multiple sclerosis and related disorders·2023
Same author

Clinical efficacy of first and second series of peptide receptor radionuclide therapy in patients with neuroendocrine neoplasm: a cohort study.

Scandinavian journal of gastroenterology·2021
Same author

Disability in progressive MS is associated with T2 lesion changes.

Multiple sclerosis and related disorders·2018
Same author

Effect on Body Weight, Quality of Life and Appetite Following Individualized, Nutritional Counselling to Home-Living Elderly after Rehabilitation - An Open Randomized Trial.

The journal of nutrition, health & aging·2017
Same author

Radiographic progression with nonrising PSA in metastatic castration-resistant prostate cancer: post hoc analysis of PREVAIL.

Prostate cancer and prostatic diseases·2017
Same author

Danish Prostate Cancer Registry - methodology and early results from a novel national database.

Clinical epidemiology·2016

Area of Science:

  • Oncology
  • Public Health
  • Epidemiology

Background:

  • Prostate cancer is a common male malignancy with a detectable preclinical period.
  • These characteristics suggest suitability for screening programs.
  • However, the disease's enigmatic epidemiology raises questions about the net benefit of widespread screening.

Purpose of the Study:

  • To evaluate the potential benefits and challenges of prostate cancer screening programs.
  • To address issues related to conducting large-scale trials for screening efficacy.

Main Methods:

  • Discussion of the criteria for initiating screening programs.
  • Identification of problems in designing and executing clinical trials for screening efficacy.
  • Emphasis on the need for comparative studies (screened vs. non-screened populations).

Related Experiment Videos

Main Results:

  • Prostate cancer's natural history supports screening feasibility.
  • Epidemiological uncertainties complicate the assessment of screening benefits.
  • The necessity of robust evidence from controlled trials is highlighted.

Conclusions:

  • While prostate cancer is detectable early, its complex epidemiology warrants caution.
  • Demonstrating a clear benefit in morbidity and mortality reduction is crucial before implementing large-scale screening.
  • Further research and well-designed trials are essential to resolve screening efficacy questions.