Related Experiment Video
Updated: Aug 18, 2026

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
Published on: January 18, 2019
Serum laminin P1 fragment concentration in renal diseases
1Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Abstract:
The serum concentration of laminin P1 fragment was determined in various histologically proven renal diseases by a competitive radioimmunoassay directed against the pepsin-resistant fragment P1. The serum laminin P1 fragment level of healthy subjects (n = 71) was 1.35 +/- 0.19 U/ml. Serum levels of laminin P1 fragment in patients with minimal change nephrosis in the remission phase and those with IgA nephropathy showed no significant difference when compared with healthy controls. However, patients with minimal change nephrosis in the nephrotic phase, membranous glomerulonephritis, diabetic nephropathy, lupus nephritis and renal cell carcinoma showed significantly higher levels (P less than 0.01) of serum laminin P1 fragment. No correlation was observed between serum laminin P1 fragment level and creatinine clearance. These results suggest that changes in serum laminin P1 fragment level could be used to indicate alterations in glomerular basement membrane metabolism in renal disease.
Related Concept Videos
Laminins are the Adhesive Proteins of Basal Lamina
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Serum Studies: Renal Function Tests

