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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.

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Related Experiment Video

Updated: Jun 14, 2026

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
12:28

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics

Published on: January 11, 2019

Targeting cellular proapoptotic molecules for developing anticancer agents from marine sources.

Xiukun Lin1, Ming Liu, Chaoxin Hu

  • 1Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Rd, Qingdao, 266071, PR China. linxiukun@yahoo.com

Current Drug Targets
|March 20, 2010
PubMed
Summary

Marine natural products show promise as anticancer drugs by inducing apoptosis, programmed cell death. Further research is needed to fully understand their mechanisms against cancer progression.

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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
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Apoptosis Induction and Detection in a Primary Culture of Sea Cucumber Intestinal Cells
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Apoptosis Induction and Detection in a Primary Culture of Sea Cucumber Intestinal Cells

Published on: January 21, 2020

Related Experiment Videos

Last Updated: Jun 14, 2026

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
12:28

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics

Published on: January 11, 2019

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

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Apoptosis Induction and Detection in a Primary Culture of Sea Cucumber Intestinal Cells
07:47

Apoptosis Induction and Detection in a Primary Culture of Sea Cucumber Intestinal Cells

Published on: January 21, 2020

Area of Science:

  • Marine biology
  • Biochemistry
  • Pharmacology

Background:

  • Apoptosis, a crucial defense against cancer, eliminates harmful cells without inflammation.
  • Targeting apoptotic pathways is a key strategy for developing novel chemotherapeutic agents.
  • Marine natural products are a growing source for discovering anticancer drugs.

Purpose of the Study:

  • To summarize marine natural products with apoptosis-inducing and anticancer activities.
  • To highlight compounds based on their effects on apoptotic signaling pathways.
  • To underscore the potential of marine-derived compounds in cancer therapy.

Main Methods:

  • Review of scientific literature on marine natural products and their anticancer properties.
  • Analysis of compounds isolated from marine organisms.
  • Categorization of compounds based on their impact on apoptotic signaling.

Main Results:

  • Several marine natural products have demonstrated apoptosis-inducing and anticancer effects.
  • These compounds offer potential therapeutic strategies for cancer treatment.
  • Most identified compounds require further in-depth mechanistic studies.

Conclusions:

  • Marine natural products represent a promising avenue for novel anticancer drug discovery.
  • Exploiting marine biodiversity can lead to the development of effective cancer therapies.
  • Understanding the mechanisms of these compounds is essential for clinical translation.