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The Obstructive Lung Disease in Northern Sweden (OLIN) longitudinal paediatric study I--the first 10 years

E Rönmark1, A Bjerg, L Hedman

  • 1The OLIN Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, Luleå, Sweden. eva.ronmark@nll.se

The Clinical Respiratory Journal
|March 20, 2010
PubMed

Insights

This prospective study followed 3525 children, revealing asthma prevalence of 6% and increasing allergic sensitization. Key risk factors for asthma and allergies grew with age, with environmental factors diminishing after age 7.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Epidemiology

Background:

  • Prospective population-based studies on childhood asthma and allergies are limited.
  • Understanding the long-term development of these conditions is crucial.

Purpose of the Study:

  • To present methods and findings from a long-term prospective study of asthma and allergic conditions in school children.
  • To analyze risk factors and disease progression over time.

Main Methods:

  • A cohort of 3525 children (aged 7/8) in Northern Sweden was followed annually.
  • Utilized expanded International Study of Asthma and Allergies in Childhood (ISAAC) protocol, skin prick tests, allergen analysis, and clinical assessments.
  • Included lung function tests, bronchial hyperreactivity tests, and serum IgE/IgG antibody analysis.

Main Results:

  • Asthma prevalence was 6% at 7-8 years, increasing with age; annual asthma remission was 5%.
  • Positive skin prick test prevalence rose from 21% to 30% between ages 7-8 and 11-12; allergic sensitization remission was rare.
  • Risk factors for asthma and sensitization intensified with age; environmental factors' impact waned after age 7. Pet avoidance showed no protective effect.

Conclusions:

  • The study provides a valuable dataset for longitudinal research on asthma and allergic sensitization development.
  • Findings highlight the dynamic nature of childhood asthma and allergies, with distinct risk factor patterns.
  • Further analysis will enhance understanding of disease trajectories and contributing factors.
Abstract

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