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Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

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Alterations in the complement cascade in post-traumatic stress disorder.

Lilit P Hovhannisyan¹, Gohar M Mkrtchyan, Samvel H Sukiasian

¹Institute of Molecular Biology of the National Academy of Sciences of Armenia.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology

|March 20, 2010

Summary

This summary is machine-generated.

This study reveals that post-traumatic stress disorder (PTSD) involves an imbalanced complement system, with specific pathway activations and deactivations. These findings highlight inflammation

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Last Updated: Jun 14, 2026

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Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

Area of Science:

Immunology
Neuroscience
Psychiatry

Background:

The complement system is a crucial mediator of immune responses.
Its role in post-traumatic stress disorder (PTSD) remains incompletely understood.

Purpose of the Study:

To investigate the functional state of the complement system in individuals with PTSD.
To determine if complement pathway activity correlates with PTSD.

Main Methods:

Assessed hemolytic activities of classical and alternative complement pathways in PTSD patients and healthy controls.
Measured individual complement component activities.
Performed correlation analysis between measured parameters.

Main Results:

Post-traumatic stress disorder (PTSD) demonstrated hyperactivation of the classical complement pathway.
Hypoactivation of the alternative complement pathway was observed in PTSD.
Overactivation of the terminal complement pathway was a key finding.

Conclusions:

The study provides evidence for the involvement of inflammatory processes in the pathogenesis of PTSD.
Complement system dysregulation may contribute to PTSD development and progression.