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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

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Microfluidics in Assessing Platelet Function
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PATCH: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trial.

Koen de Gans1, Rob J de Haan, Charles B Majoie

  • 1Department of Neurology, Academic Medical Centre, H2-222, PO-box 22660 1100 DD Amsterdam, The Netherlands. k.degans@amc.uva.nl

BMC Neurology
|March 20, 2010
PubMed
Summary

Platelet transfusion may improve outcomes for patients with intracerebral hemorrhage on antiplatelet therapy. This randomized trial investigates its safety and efficacy in reducing hematoma growth and improving functional health.

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Area of Science:

  • Neurology
  • Hematology
  • Critical Care Medicine

Background:

  • Intracerebral hemorrhage (ICH) carries a poor prognosis, particularly for patients on antiplatelet therapy.
  • Early hematoma expansion is a key determinant of outcome in ICH.
  • Current acute treatment options for ICH are limited.

Purpose of the Study:

  • To determine if platelet transfusion improves outcomes in ICH patients using antiplatelet treatment.
  • To evaluate the safety and efficacy of platelet transfusion in this patient population.

Main Methods:

  • Prospective, randomized, multi-center study (PATCH study).
  • Patients randomized to receive platelet transfusion within six hours or standard care.
  • Primary endpoint: functional health at three months; secondary endpoints: safety and hematoma growth.

Main Results:

  • This section is not available in the provided abstract.

Conclusions:

  • This is the first randomized controlled trial investigating platelet transfusion for acute hemorrhagic disease.
  • Platelet transfusion is a potential therapeutic strategy for ICH patients on antiplatelet therapy.