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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Drug Delivery Systems: Different Types

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

Oral Drug Delivery Systems: Introduction

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

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Updated: Jun 14, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Silk-based delivery systems of bioactive molecules.

Keiji Numata¹, David L Kaplan

¹Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

Advanced Drug Delivery Reviews

|March 20, 2010

Summary

Silk proteins offer versatile, biodegradable platforms for drug and gene delivery. Genetically engineered silks can be tailored for various biomedical applications, enhancing bioactive molecule transport.

Area of Science:

Biomaterials Science
Protein Engineering
Drug Delivery Systems

Background:

Silks are natural, biodegradable, and biocompatible proteins with a history of biomedical use.
Genetic engineering allows tailoring silk proteins for specific chemical properties and functionalities.
Recent FDA approval expands the utility of silk in biomaterials devices.

Purpose of the Study:

To review the biosynthesis of silk-based multi-block copolymer systems.
To explore the applications of silk protein drug delivery systems.
To assess the utility of silk systems for delivering small molecule drugs, proteins, and genes.

Main Methods:

Review of scientific literature on silk biosynthesis and applications.
Analysis of silk-based multi-block copolymer systems.

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Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

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Last Updated: Jun 14, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles

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Published on: October 8, 2016

Silk Film Culture System for in vitro Analysis and Biomaterial Design

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Published on: April 24, 2012

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Examination of silk protein drug delivery strategies.

Main Results:

Silk proteins can be engineered for controlled size, structure, and chemistry.
Silk-based systems demonstrate potential for delivering various bioactive molecules.
Multi-block copolymer systems offer advanced possibilities for drug encapsulation and release.

Conclusions:

Engineered silk proteins represent a promising class of biomaterials for advanced drug and gene delivery.
Silk-based systems provide tunable platforms for targeted delivery of therapeutics.
Further research into silk biosynthesis and copolymer systems will expand their biomedical applications.