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Related Concept Videos

Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview

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Related Experiment Video

Updated: Jun 14, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

SeSAW: balancing sequence and structural information in protein functional mapping.

Daron M Standley1, Reiko Yamashita, Akira R Kinjo

  • 1WPI Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, Japan. standley@ifrec.osaka-u.ac.jp

Bioinformatics (Oxford, England)
|March 20, 2010
PubMed
Summary
This summary is machine-generated.

SeSAW identifies conserved protein motifs by analyzing sequence and structural similarities. This tool helps visualize functional conservation in 2D alignments and 3D structures for proteins.

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Last Updated: Jun 14, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

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Published on: July 14, 2015

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Functional similarity in proteins is observable at both sequence and structural levels.
  • Identifying conserved motifs is crucial for understanding protein function and evolution.

Purpose of the Study:

  • To introduce SeSAW, a web-based program for identifying conserved motifs in protein structures.
  • To enable quantification of sequence and structural similarities at the residue level.

Main Methods:

  • SeSAW locates and quantifies sequence and structural similarities within protein structures.
  • The program analyzes both experimentally determined structures and homology models.
  • Results are visualized through 2D annotated alignments and 3D structural superpositions.

Main Results:

  • SeSAW successfully identifies functionally and evolutionarily conserved motifs.
  • The tool provides detailed residue-level similarity quantification.
  • Visualization options enhance the interpretation of conserved regions.

Conclusions:

  • SeSAW is a valuable tool for researchers studying protein function and evolution.
  • The web server offers an accessible platform for motif discovery and analysis.
  • The visualization features aid in understanding protein conservation patterns.