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Novel hemostatic factor levels and risk of ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study

M Fareed K Suri1, Kazumasa Yamagishi, Nena Aleksic

  • 1Department of Neurology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Cerebrovascular Diseases (Basel, Switzerland)
|March 20, 2010
PubMed

Insights

Higher levels of factor XI, a clotting protein, are linked to an increased risk of ischemic stroke. This finding may help identify individuals at greater risk for stroke.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Epidemiology

Background:

  • The association between hemostatic factor levels and cerebral infarction (ischemic stroke) is not fully understood.
  • Several under-studied hemostatic factors require investigation in relation to stroke risk.

Purpose of the Study:

  • To investigate the association of specific hemostatic factor levels with the incidence of ischemic stroke.
  • To identify potential biomarkers for predicting ischemic stroke risk in a population-based cohort.

Main Methods:

  • Utilized a case-cohort design within the Atherosclerosis Risk in Communities (ARIC) study (n=15,792).
  • Measured levels of hemostatic factors (II, V, IX, X, XI, XII, plasminogen, alpha(2)-antiplasmin) in plasma samples.
  • Employed multivariate proportional hazard regression analyses to assess associations with incident ischemic stroke over a median of 7.5 years.

Main Results:

  • Elevated levels of factor XI, factor IX, and alpha(2)-antiplasmin were initially associated with increased ischemic stroke risk (highest vs. lowest quartiles).
  • After multivariate adjustment, only higher factor XI levels remained significantly associated with an increased risk of ischemic stroke (HR 1.50, 95% CI 1.10-2.05).

Conclusions:

  • Increased levels of factor XI are associated with a higher risk of developing ischemic stroke.
  • Factor XI may serve as a valuable biomarker for identifying individuals at elevated risk of ischemic stroke.
Abstract

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