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Long-term trends in adherence to antiretroviral therapy from start of HAART

Valentina Cambiano1, Fiona C Lampe, Alison J Rodger

  • 1HIV Epidemiology & Biostatistics Group, Research Department of Infection & Population Health, UCL Medical School, Royal Free Campus, London, UK. v.cambiano@ucl.ac.uk

AIDS (London, England)
|March 20, 2010
PubMed

Insights

Highly active antiretroviral therapy (HAART) adherence remains stable over a decade. This long-term adherence suggests sustained viral suppression is achievable for patients on HAART.

Area of Science:

  • HIV/AIDS research
  • Pharmacology
  • Public health

Background:

  • Antiretroviral therapy (ART) requires lifelong adherence for sustained viral suppression.
  • Long-term adherence trends and predictors in highly active antiretroviral therapy (HAART) are crucial for patient management.

Purpose of the Study:

  • To investigate long-term trends in HAART adherence.
  • To identify key predictors of adherence.
  • To assess the occurrence of periods with low adherence (

Main Methods:

  • Followed participants from HAART initiation until last ART prescription or death.
  • Calculated adherence every 6 months based on prescription coverage for at least three antiretroviral drugs.
  • Analyzed adherence trends and predictors over time.

Main Results:

  • Adherence showed a slight increase over time (OR=1.02 per year).
  • Independent predictors included age, demographics, calendar year, drug regimen, and prior virologic failures.
  • The rate of low adherence decreased significantly over time.

Conclusions:

  • Drug coverage adherence remains stable on average for over a decade of HAART.
  • Sustained adherence indicates potential for long-term viral suppression in patients.
  • Long-term HAART adherence is feasible and supports chronic HIV management.
Abstract

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