Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Computed Tomography

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

Phase Contrast and Differential Interference Contrast Microscopy

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preclinical Safety and Feasibility Study of Line-Field Confocal Optical Coherence Tomography for Ophthalmology Applications.

Translational vision science & technology·2026

Same author

Energy scaling and propagation properties of Laguerre-Gauss modes in gas-filled multipass cells.

Optics express·2026

Same author

UV electro-optic frequency comb hybrid fiber/bulk laser system for molecular wind lidar.

Optics express·2026

Same author

Editorial: Innovative approaches to nutrition counseling in pediatric dietetics - guidelines, practices, and future directions.

Frontiers in nutrition·2026

Same author

Substantial aircraft contrail formation at low soot emission levels.

Nature·2026

Same author

Low-noise generation of UV dispersive waves at 100 kHz.

Optics letters·2026

Search research articles

Related Experiment Video

Updated: Jun 14, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

Motion artifact suppression in full-field optical coherence tomography.

Delphine Sacchet¹, Michal Brzezinski, Julien Moreau

¹Laboratoire Charles Fabry de l'Institut d'Optique, CNRS UMR 8501, Université Paris-Sud, Campus Polytechnique, RD128, 91127 Palaiseau Cedex, France. delphine.sacchet@institutoptique.fr

|March 20, 2010

Summary

This study introduces a novel full-field optical coherence tomography (FF-OCT) system that significantly reduces motion artifacts in in-vivo imaging. The new system utilizes instantaneous phase shifting and pulsed illumination for clearer, artifact-free tomographic images.

More Related Videos

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

Related Experiment Videos

Last Updated: Jun 14, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

Area of Science:

Biomedical Optics
Optical Imaging
Interferometry

Background:

Conventional full-field optical coherence tomography (FF-OCT) systems suffer from significant motion artifacts, limiting their effectiveness for in-vivo imaging.
Addressing these motion artifacts is crucial for improving the diagnostic capabilities of FF-OCT.

Purpose of the Study:

To theoretically and experimentally investigate the limitations of conventional FF-OCT due to motion artifacts.
To demonstrate a new FF-OCT system capable of suppressing motion artifacts for enhanced in-vivo imaging.

Main Methods:

Developed a novel FF-OCT system employing instantaneous phase shifting with nonpolarizing optics and pulsed illumination.
Utilized a Linnik-type interferometer illuminated by superluminescence emission from a Ti:Al(2)O(3) waveguide crystal.
Acquired en face tomographic images by combining two simultaneously captured, phase-opposed interferometric images from two CCD cameras.

Main Results:

The new FF-OCT system effectively suppressed most motion artifacts.
Achieved a spatial resolution of 0.8 microm (axial) x 1.6 microm (transverse).
Demonstrated a detection sensitivity of approximately 60 dB.

Conclusions:

The presented FF-OCT system offers a significant improvement over conventional methods by mitigating motion artifacts.
This advancement holds promise for more reliable and detailed in-vivo imaging applications.
The system's high resolution and sensitivity enable clearer visualization of biological structures.