Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased Risk of Spontaneous Bacterial Peritonitis in Cirrhotic Patients Using Proton Pump Inhibitors.

GE Portuguese journal of gastroenterology·2019
Same author

Elusive Cardiac Angiosarcoma in a Young Pregnant Female: Rare Presentation With Fatal Outcome.

Cardiology research·2017
Same author

A case of successful remission of extensive primary gastric diffuse large B cell lymphoma: radiologic, endoscopic and pathologic evidence.

Case reports in gastroenterology·2014
Same author

Ethical concerns in early 21(st) century organ transplantation.

Journal of medical ethics and history of medicine·2013
Same author

Tuberculous peritonitis associated with peritoneal dialysis.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia·2012
Same author

Eosinophilic pneumonia: experience at two tertiary care referral hospitals in Saudi Arabia.

Annals of Saudi medicine·2011

Related Experiment Video

Updated: Jun 14, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Revisiting Methicillin-Resistant Staphylococcus aureus Infections.

Abdelkarim Waness1

  • 1Division of Internal Medicine, King Abdulaziz Medical City, Department of Medicine, Code #1443, P.O. Box 22490, Riyadh 11465, Saudi Arabia.

Journal of Global Infectious Diseases
|March 20, 2010
PubMed
Summary

Methicillin-resistant Staphylococcus aureus (MRSA) infections are increasingly common in the community, even among healthy individuals. This review covers MRSA history, spread, and management strategies for this growing epidemic.

Keywords:
Blood cultureslinezolidmethicillin-resistant Staphylococcus aureussepsisvancomycin

Related Experiment Videos

Last Updated: Jun 14, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) has rapidly emerged as a global health threat.
  • MRSA is no longer confined to healthcare settings, with rising community-acquired infections.
  • The increasing prevalence necessitates a comprehensive understanding of its epidemiology and clinical impact.

Purpose of the Study:

  • To present a case of community-associated MRSA sepsis.
  • To provide a comprehensive review of MRSA infections.
  • To discuss the history, pathogenesis, epidemiology, diagnostics, treatment, and contributing factors of MRSA.

Main Methods:

  • Case presentation of community-associated MRSA sepsis.
  • Literature review on MRSA history, pathogenesis, and epidemiology.
  • Analysis of clinical presentations, diagnostic methods, and therapeutic options.
  • Examination of contributing factors and economic impact.

Main Results:

  • Community-associated MRSA sepsis presents a significant clinical challenge.
  • MRSA infections exhibit diverse clinical presentations and require specific diagnostic approaches.
  • Effective therapeutic strategies are crucial for managing MRSA infections.
  • Understanding contributing factors is key to controlling the MRSA epidemic.

Conclusions:

  • Community-acquired MRSA infections represent a growing public health concern.
  • A multidisciplinary approach is essential for effective MRSA prevention and treatment.
  • Continued research into MRSA pathogenesis and resistance mechanisms is vital.