Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy.

Neurobiology of disease·2025
Same author

Identifying consensus and areas for future research in chondrosarcoma : a report from the Birmingham Orthopaedic Oncology Meeting.

The bone & joint journal·2025
Same author

Controversies in orthopaedic oncology.

The bone & joint journal·2024
Same author

Scrutinizing the use of contrasted chest CTs in extremity sarcoma staging and surveillance.

Journal of surgical oncology·2023
Same author

Correction to: Machine learning for rhabdomyosarcoma histopathology.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2022
Same author

Machine learning for rhabdomyosarcoma histopathology.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2022
Same journal

Correction to "Prospective Evaluation of Complications and Associated Risk Factors in Breast Cancer Surgery".

Journal of oncology·2026
Same journal

Correction to "Clusterin Silencing in Prostate Cancer Induces Matrix Metalloproteinases by an NF-κB-Dependent Mechanism".

Journal of oncology·2026
Same journal

RETRACTION: All-Trans Retinoic Acid Enhances Chemosensitivity to 5-FU by Targeting miR-378c/E2F7 Axis in Colorectal Cancer.

Journal of oncology·2026
Same journal

RETRACTION: UBE2C Induces Cisplatin Resistance via ZEB1/2-Dependent Upregulation of ABCG2 and ERCC1 in NSCLC Cells.

Journal of oncology·2026
Same journal

RETRACTION: Alternatively Expressed Transcripts Analysis of Non-Small Cell Lung Cancer Cells under Different Hypoxic Microenvironment.

Journal of oncology·2026
Same journal

RETRACTION: Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres.

Journal of oncology·2025
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

Is There a Predisposition Gene for Ewing's Sarcoma?

R L Randall1, S L Lessnick, K B Jones

  • 1Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute and Primary, Children's Medical Center, The University of Utah, Utah, UT 84112, USA.

Journal of Oncology
|March 20, 2010
PubMed
Summary
This summary is machine-generated.

Ewing's sarcoma, a rare childhood cancer, is primarily linked to EWSR1 gene fusions. Research is exploring potential genetic predispositions, as familial cases are currently unreported, suggesting a need for further investigation into hereditary factors.

More Related Videos

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Jun 14, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ewing's sarcoma is a highly malignant bone and soft tissue tumor affecting children and young adults.
  • Most cases exhibit EWSR1 gene fusions with ETS family genes, but other genetic alterations are inconsistently identified.
  • The potential for a heritable predisposition to Ewing's sarcoma remains largely unexplored.

Purpose of the Study:

  • To review the current evidence regarding hereditary factors in Ewing's sarcoma development.
  • To investigate the possibility of undiscovered recurrent genetic abnormalities in Ewing's sarcoma.
  • To assess the potential for identifying susceptibility loci through familial case studies.

Main Methods:

  • Review of existing literature on Ewing's sarcoma genetics and familial cancer syndromes.
  • Analysis of reported cases, including sibling pairs and secondary malignancies.
  • Discussion of traditional genetic mapping techniques for identifying susceptibility loci.

Main Results:

  • EWSR1 gene fusions are the most consistent molecular alteration found in Ewing's sarcoma.
  • Cooperative genetic events like TP53 mutations or CDKN2A deletions are infrequent.
  • No significant associations with classic tumor susceptibility syndromes have been identified, and familial cases are unreported.

Conclusions:

  • While EWSR1 gene fusions are central to Ewing's sarcoma, other contributing genetic factors, potentially heritable, require further investigation.
  • The absence of reported familial cases and links to known syndromes highlights a gap in understanding Ewing's sarcoma etiology.
  • Future research should focus on identifying novel genetic alterations and exploring potential hereditary components.