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Controlled reagent transport in disposable 2D paper networks
Elain Fu1, Barry Lutz, Peter Kauffman
1Box 355061, Department of Bioengineering, University of Washington, Seattle, WA, USA. efu@u.washington.edu
Lab on a Chip
|March 20, 2010
Summary
This study shows how to control fluid flow in 2D paper networks using network geometry and dissolvable barriers. This enables precise reagent delivery for enhanced detection sensitivity in paper-based devices.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Materials Science
Background:
- Paper-based analytical devices (PADs) are emerging as low-cost diagnostics.
- Previous work demonstrated multi-analyte detection using paper networks with multiple outlets.
- Controlling fluid flow in PADs is crucial for complex assays.
Purpose of the Study:
- To investigate the capabilities of 2D paper networks with multiple inlets per outlet.
- To demonstrate controlled reagent transport within these paper devices.
- To explore implications for enhanced detection sensitivity.
Main Methods:
- Utilized 2D paper networks with multiple inlets and a single outlet.
- Employed network geometry to direct fluid flow.
- Incorporated dissolvable barriers to regulate reagent release and transport.
Main Results:
- Successfully demonstrated controlled, sequential transport of reagents within the 2D paper network.
- Showcased how network design dictates fluid pathways.
- Dissolvable barriers effectively managed reagent delivery timing.
Conclusions:
- 2D paper networks with multiple inlets offer precise fluid control.
- Network geometry and dissolvable barriers are effective tools for managing reagent transport.
- This approach holds promise for developing more sensitive paper-based diagnostic assays.
