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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
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Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...

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Related Experiment Video

Updated: Jun 14, 2026

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

[Circadian rhythmicity and addiction].

Ana Adan

    Adicciones
    |March 20, 2010
    PubMed
    Summary

    This study explores how circadian rhythms influence addiction. Disruptions in biological clocks and specific clock genes (Clock, Per2) are linked to addiction vulnerability and treatment strategies.

    Area of Science:

    • Chronobiology
    • Neuroscience
    • Addiction Research

    Background:

    • Drug consumption negatively impacts circadian rhythmicity, causing flattened functions and delayed peak values.
    • Circadian rhythm disruption can lead to desynchronization of endogenous control systems.
    • Research highlights the role of chronobiology in understanding addiction.

    Discussion:

    • Clock genes (Clock and Per2) are associated with addiction vulnerability.
    • Clock gene regulates dopaminergic activity in the reward system.
    • Per2 gene influences drug sensitivity and withdrawal symptoms.

    Key Insights:

    • Evening circadian typology is a potential risk factor for drug addiction.
    • Individual differences in circadian timing affect addiction susceptibility.

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    Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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    Last Updated: Jun 14, 2026

    Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
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    Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
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    Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

    Published on: December 16, 2022

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  • Understanding chronotype is crucial for addiction risk assessment.

    • Outlook:

    • Reorganizing circadian rhythmicity through light-dark cycles and schedules may aid addiction treatment.
    • Light exposure (natural or artificial) and melatonin administration are potential therapeutic strategies.
    • Chronobiological interventions offer novel avenues for managing drug addiction.