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Updated: Jun 14, 2026

Gas Chromatography-Mass Spectrometry Paired with Total Vaporization Solid-Phase Microextraction as a Forensic Tool
Published on: May 25, 2021
Collaboration between medical examiner and toxicologist-analyst
1Institute of Forensic Medicine, School of Medicine, Comenius University and Healthcare Surveillance Authority, Bratislava, Slovakia.
Abstract:
Negative effects of the increasing number of toxic substances in the external environment affecting the human organism are highly reflected in everyday forensic practice. In parallel with new circumstances also the methods enabling identification of heterogeneous substances have been developing. Demonstrating evidence is more challenging and sophisticated particularly in cases with proving several xenobiotics including metabolites and their possible interaction. Poison intoxications of unknown origin can represent a diagnostic problem. Consequently close collaboration between involved forensic professionals i.e. medical examiner and forensic toxicologist-analyst is inevitable. The data provided by police investigators are significant as well--investigated circumstances, testimonies and in case of hospitalization detailed data from clinicians. In everyday forensic practice the shortage of medical examiners specialised in toxicology and knowledgeable toxicologists-analysts has been increasingly experienced. The urgent requirement for more specialists arises more frequently not only in suspected fatal poisonings but also in assessing of analysis results particularly in cases of persons directly involved in road traffic accidents, work-related injuries, etc. The number of cases requiring detecting psychoactive substances is also increasing. On the other hand recent experience demands expanding the spectrum and increasing the number of indications of toxicological analyses from medical examiners involved in performing autopsies. At present the Slovak forensic workplaces are in the process of being equipped with instrumentation designed for expanding the spectrum of toxicological analyses and improving their quality. There hence emerges a need for developing the contemporary concept of Slovak forensic toxicology with respect to both organizational and methodological aspects focused on better interaction of activities carried out by medical examiners and toxicologist-analysts. The essential part of developing the coordination of both expert groups is also postgraduate education with an emphasis on improving mutual recognition principles of their work.
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