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Updated: Jun 14, 2026

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)
Published on: November 22, 2016
Phosphinite thioethers derived from chiral epoxides. Modular P,S-ligands for Pd-catalyzed asymmetric allylic
Xisco Caldentey1, Miquel A Pericàs
1Institute of Chemical Research of Catalonia (ICIQ), Av. Paisos Catalans 16, E-43007 Tarragona, Spain.
Abstract:
A new family of modular P,S-ligands has been prepared from enantiopure arylglycidols. These ligands have been iteratively optimized with respect to four different structural parameters for use in Pd-catalyzed allylic substitutions. As a final output, highly active and enantioselective ligands for these synthetically important transformations have been developed, and the factors controlling their catalytic behavior have been rationalized. From a methodological point of view, a convenient procedure for the regioselective ring-opening of cis-glycidic esters with bulky thiols to yield the corresponding beta-alkylthio-alpha-hydroxy carboxylic acids has been developed.
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