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[Association between methylthioadenosine phosphorylase gene single nucleotide polymorphisms and myocardial infarction

Qi Zhang1, Shuang-shuang Cheng, Jie Yan

  • 1Department of Cardiology, the Affiliated Hospital of North China Coal Medical College, Tangshan 063000, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|March 23, 2010
PubMed

Insights

Methylthioadenosine phosphorylase (MTAP) gene single nucleotide polymorphisms (SNPs) were studied for association with myocardial infarction (MI) in Chinese Han individuals. A specific SNP, rs7027989, showed increased MI risk in males.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Pharmacogenomics

Background:

  • Myocardial infarction (MI) is a leading cause of mortality globally.
  • Genetic factors play a role in MI susceptibility.
  • The methylthioadenosine phosphorylase (MTAP) gene is a potential candidate for influencing cardiovascular health.

Purpose of the Study:

  • To examine the association between single nucleotide polymorphisms (SNPs) in the MTAP gene and the risk of MI.
  • To investigate this relationship specifically within the Chinese Han population.

Main Methods:

  • A case-control study involving 432 MI patients and 430 healthy controls.
  • Genotyping of nine tag SNPs within the MTAP gene.
  • Stratified analysis based on gender.

Main Results:

  • No overall significant association was found between the selected MTAP SNPs and MI across all participants.
  • However, a significant association was detected for the rs7027989 SNP in male subjects.
  • Male carriers of the minor allele at rs7027989 had a 26% increased risk of MI (P = 0.005), even after adjusting for confounders.

Conclusions:

  • The MTAP gene, particularly the rs7027989 polymorphism, may contribute to the development of MI in the Chinese Han male population.
  • Further research is warranted to elucidate the precise mechanisms linking MTAP to MI etiology.
Abstract

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