Related Experiment Video
Updated: Jun 14, 2026
A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
Published on: October 14, 2016
[Clinical features and prognosis of acute myeloid leukemia-M(4).]
Wei Li1, Ying-Chang Mi, Ying Wang
1Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020,China.
Objective:
To investigate factors that affect survival and prognosis of acute myeloid leukemia (AML)-M(4).
Methods:
Seventy AML-M(4) patients were divided into three groups, neither eosinophilia nor inv(16)\[Eos(-)\], eosinophilia with inv (16)\[Eos(+) inv(16)(+)\], and eosinophilia with no inv(16)\[Eos(+) inv(16)(-)\]. Clinical features, immunophenotype, chromosome karyotype, overall survival (OS) and relapse-free survival (RFS) were analyzed.
Results:
The total complete remssion (CR) rate was 85.7%, CR rate after the first course of induction therapy was 71.4%. The median OS was 20 (1.2 - 162.4) months, and median RFS 78.0 (1.2 - 129.5) months. The 3 and 5 year OS rates were 42% and 42%, and 3 and 5 year RFS rates were 59% and 54%, respectively. The CR rate, CR after the first course of induction therapy and the median OS for the Eos(-) group were 76.9%, 61.5% and 11.2 (1.2 - 162.4) months; for the Eos(+) group were 96.8%, 89.6% and did not reach; for the Eos(+)inv16(+) group were 100%, 94.4% and did not reach; and for the Eos(+) inv(16)(-) group were 91.7%,69.2% and 14.3 months respectively. The statistical assay showed significant difference between Eos(+)inv(16)(-) and Eos(+)inv(16)(+) groups in OS. The Eos(+) patients present with early onset and low count of platelets.
Conclusion:
Eosinophilia emerged as a favorable prognostic factor, and the concomitant presence of both eosinophilia and inv(16) is associated with a significantly favorlable prognosis.
Insights
Eosinophilia is a positive prognostic factor in acute myeloid leukemia (AML)-M(4) patients. The presence of both eosinophilia and the inv(16) chromosomal abnormality indicates a significantly better prognosis for AML-M(4).
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Acute myeloid leukemia (AML)-M(4) is a subtype with variable prognoses.
- Identifying prognostic factors is crucial for tailoring treatment strategies.
Purpose of the Study:
- To investigate the impact of eosinophilia and the inv(16) chromosomal abnormality on the survival and prognosis of AML-M(4) patients.
Main Methods:
- Seventy AML-M(4) patients were categorized into three groups based on eosinophilia and inv(16) status.
- Analysis included clinical features, immunophenotype, karyotype, overall survival (OS), and relapse-free survival (RFS).
Main Results:
- Complete remission rates were high across groups, with the eosinophilia-positive groups showing better outcomes.
- Patients with both eosinophilia and inv(16) had significantly longer OS and RFS.
- Eosinophilia alone was also associated with improved survival, though less pronounced than the combined factors.
Conclusions:
- Eosinophilia is a favorable prognostic indicator in AML-M(4).
- The co-occurrence of eosinophilia and the inv(16) abnormality confers a significantly better prognosis.
- These findings can aid in risk stratification and personalized treatment for AML-M(4).
Related Concept Videos
01:15Differentiation of Common Myeloid Progenitor Cells
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:27Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...