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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Updated: Jun 14, 2026

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

Endocannabinoids and pregnancy.

Anthony H Taylor1, Akwasi A Amoako, Katerina Bambang

  • 1Reproductive Sciences Section, University of Leicester, Leicester, United Kingdom.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 23, 2010
PubMed
Summary
This summary is machine-generated.

The endocannabinoid system (ECS) significantly impacts human reproduction, influencing fertility and pregnancy outcomes. Anandamide (AEA) and related compounds are key players in reproductive processes and may serve as diagnostic markers.

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Published on: August 1, 2025

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Molecular biology

Background:

  • The endocannabinoid system (ECS) comprises endocannabinoids like anandamide (AEA), their receptors, and associated enzymes.
  • The precise cellular and molecular mechanisms governing ECS functions are not fully understood.
  • Emerging evidence highlights the ECS's crucial role in human reproduction.

Purpose of the Study:

  • To review the current understanding of the ECS's involvement in human reproduction.
  • To explore the role of AEA and other ECS components in reproductive functions.
  • To discuss the potential of AEA as a diagnostic marker for reproductive outcomes.

Main Methods:

  • Literature review of studies on the ECS and human reproduction.
  • Analysis of research on AEA and related endocannabinoids.
  • Examination of evidence for ECS involvement in oogenesis, embryo transport, implantation, and placental development.

Main Results:

  • The ECS regulates key reproductive processes including oogenesis, embryo transport, and implantation.
  • AEA and related ECS elements are involved in placental development and pregnancy outcomes.
  • Sperm function, including survival, motility, capacitation, and acrosome reaction, is influenced by the ECS.
  • Plasma and tissue AEA levels may serve as diagnostic markers for reproductive success.

Conclusions:

  • The ECS plays a multifaceted role in human reproduction, from gamete function to pregnancy outcomes.
  • Further research into the ECS could lead to novel diagnostic and therapeutic strategies for reproductive health.
  • Anandamide (AEA) shows promise as a biomarker for assessing reproductive status and predicting outcomes.