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Marfan syndrome and schizophrenia: a case report and literature review

Mary Lemberg1, Alexander W Thompson

  • 1University of Washington Medical Center, Box 356560, Seattle, WA 98195-6560, USA.

General Hospital Psychiatry
|March 23, 2010
PubMed
Abstract

Insights

Marfan Syndrome (MFS), a microfibril disease, and schizophrenia may share a common cause related to abnormal growth factor expression. This suggests MFS patients need psychiatric monitoring and vice versa for better treatment.

Area of Science:

  • Genetics
  • Neuroscience
  • Connective Tissue Disorders

Background:

  • Marfan Syndrome (MFS) is a genetic disorder affecting connective tissue due to microfibril dysfunction.
  • Multiple case reports suggest an association between Marfan Syndrome and schizophrenia.
  • Understanding this link may reveal shared underlying biological pathways.

Observation:

  • This study presents a case report and literature review on the co-occurrence of Marfan Syndrome and schizophrenia.
  • The review explores potential shared etiologic pathways between these distinct conditions.

Findings:

  • A potential shared mechanism involves the abnormal expression of growth factors and disrupted signaling cascades.
  • This points to a possible molecular link between connective tissue abnormalities and psychiatric disorders.

Implications:

  • Patients with Marfan Syndrome should be screened for psychiatric symptoms.
  • Individuals exhibiting signs of Marfan Syndrome require prompt medical evaluation.
  • Investigating shared mechanisms can lead to improved diagnostic and therapeutic strategies for both conditions.

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