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VEGFA +936C>T polymorphism and cancer risk: a meta-analysis
1Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Cancer Genetics and Cytogenetics
|March 23, 2010
Summary
The VEGFA +936C>T gene polymorphism is linked to an increased risk of oral cancer. This meta-analysis of 29 studies suggests the T allele may elevate oral cancer risk, warranting further investigation.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Vascular endothelial growth factor A (VEGF-A) is crucial in angiogenesis, impacting cancer etiology and metastasis.
- The VEGFA +936C>T polymorphism in the 3'-untranslated region is associated with VEGF-A protein levels and has been linked to cancer risk, but findings are inconsistent.
Purpose of the Study:
- To conduct a meta-analysis to precisely estimate the association between the VEGFA +936C>T polymorphism and cancer risk.
- To clarify the conflicting data regarding the role of this polymorphism in cancer development.
Main Methods:
- A meta-analysis was performed on data from 29 case-control studies.
- Included were 13,293 cancer cases and 12,308 control subjects.
- Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the risk association.
Main Results:
- The meta-analysis indicated an increased risk of oral cancer in individuals with the +936 T allele (OR = 1.39, 95% CI = 1.03-1.88).
- No significant association was found for the overall cancer risk when comparing T versus C alleles (OR = 1.00, 95% CI = 0.91-1.10).
Conclusions:
- The VEGFA +936C>T polymorphism, specifically the T allele, is associated with an elevated risk of oral cancer.
- Further large-scale prospective studies are necessary to confirm these findings and draw comprehensive conclusions about the VEGFA +936C>T polymorphism and overall cancer risk.
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