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Published on: November 10, 2021

Association of proinflammatory cytokines with end stage renal disease

Gaurav Tripathi1, Minal Borkar, Ariz Akhter

  • 1Department of Urology, Chatrapati Sahuji Maharaj Medical University, Lucknow, India.

Cytokine
|March 23, 2010
PubMed
Abstract

Insights

Genetic variations in macrophage migration inhibitory factor (MIF) and interferon-gamma (IFN-gamma) are linked to end-stage renal disease (ESRD) susceptibility. High-producing genotypes of these cytokines significantly increase ESRD risk.

Area of Science:

  • Immunogenetics
  • Nephrology
  • Molecular Biology

Background:

  • Cytokines, including macrophage migration inhibitory factor (MIF) and interferon-gamma (IFN-gamma), are implicated in kidney disease pathogenesis.
  • MIF and IFN-gamma are key proinflammatory cytokines involved in inflammatory diseases.

Purpose of the Study:

  • To investigate the association between MIF -173 G/C, IFN-gamma +874 A/T, and IFN-gamma CA repeat microsatellite gene polymorphisms and susceptibility to end-stage renal disease (ESRD).

Main Methods:

  • Genotyping of MIF and IFN-gamma polymorphisms in 258 ESRD patients and 569 healthy controls.
  • Utilized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), gene sequencing, and gene scanning techniques.

Main Results:

  • Higher frequency of high-producer MIF -173 CC genotype (10.1%) in ESRD patients compared to controls (1.2%) (OR=8.9).
  • Significant differences in genotype and allelic frequencies for IFN-gamma +874 A/T and IFN-gamma CA microsatellite polymorphisms between ESRD patients and controls.
  • Combined analysis indicated an approximately 9-fold increased risk for ESRD in patients with high MIF and IFN-gamma producing phenotypes.

Conclusions:

  • The study highlights the significant role of MIF and IFN-gamma gene polymorphisms in the susceptibility to end-stage renal disease.
  • These findings underscore the importance of MIF and IFN-gamma in the inflammatory pathways contributing to ESRD development.

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