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Normal P300 following extensive damage to the left medial temporal lobe
M D Rugg1, C D Pickles, D D Potter
1Wellcome Brain Research Group, Department of Psychology, University of St Andrews, UK.
Journal of Neurology, Neurosurgery, and Psychiatry
|March 1, 1991
Abstract:
Event-related potentials (ERPs) were recorded during auditory and visual "oddball" tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.