[Quality of the antiretrovirals drug interactions database]

To identify antiretrovirals drug interaction databases (ADID) and evaluate its structural quality.

A literature search in Medline and a grey literature search were conducted. The identified ADID underwent scrutiny based on exclusion criteria and structural quality (4 minimum quality criteria: stratification by level of severity, classification by level of evidence, bibliographic data, description of the clinical management) and 11 criteria that provide the relative importance (specific weight). We analyzed the degree of compliance of the criteria in each ADID and the degree of compliance of each criterion in all ADID.

We identified 81 databases but only 8 of them were included for the analysis. Only 3 of them reached the minimum criteria: HIV-Drug interactions, Clinical Care Options HIV (The Drug-Drug Interactions Tool) and InteraccionesHIV.com. All the databases included are presented on computerized support, organized by active drug and describe clinical management; 7 of them inform about the interaction mechanism of action and have multicheck structure that speeds up the search; 4 declare they have no conflict of interest and stratifies by level of severity; 5 contain bibliographic reference; none of them classifies by level of evidence.

There are many antiretroviral interaction databases available. The knowledge about their quality structure will help provide appropriate information.