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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Crohn's disease
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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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Autoinflammatory disease reloaded: a clinical perspective.

Daniel L Kastner1, Ivona Aksentijevich, Raphaela Goldbach-Mansky

  • 1Laboratory of Clinical Investigation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. kastnerd@mail.nih.gov

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Summary

The study highlights rapid advancements in understanding autoinflammatory disease causes. These breakthroughs pave the way for new therapies and a potential redefinition of these conditions.

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Published on: May 16, 2016

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Autoinflammatory diseases are a group of genetic disorders characterized by recurrent episodes of inflammation.
  • The precise etiology of many autoinflammatory diseases remains incompletely understood.
  • Recent research has identified novel genetic mutations and molecular pathways involved in autoinflammation.

Purpose of the Study:

  • To review recent advances in the understanding of autoinflammatory disease etiology.
  • To discuss the implications of these advances for therapeutic interventions.
  • To propose a reassessment of the current definition of autoinflammatory diseases.

Main Methods:

  • Literature review of recent publications on autoinflammatory diseases.
  • Analysis of genetic and molecular data from patients with autoinflammatory diseases.
  • Discussion of emerging therapeutic strategies targeting specific inflammatory pathways.

Main Results:

  • Identification of new genes and pathways implicated in autoinflammatory diseases.
  • Demonstration of the efficacy of targeted therapies in preclinical and clinical studies.
  • Growing evidence suggests a spectrum of autoinflammatory conditions rather than distinct entities.

Conclusions:

  • Advances in understanding autoinflammatory disease etiology are rapidly evolving.
  • New therapeutic opportunities are emerging based on targeted molecular interventions.
  • The current definition of autoinflammatory diseases requires reevaluation in light of new scientific evidence.