Related Experiment Video
Updated: Jun 14, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
Published on: June 7, 2024
Immunity, inflammation, and cancer
Sergei I Grivennikov1, Florian R Greten, Michael Karin
1Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, 92093, USA.
Abstract:
Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention.
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Psychoneuroimmunology: Diabetes and Cancer
Tumor Immunotherapy
Inflammatory Bowel Disease III: Crohn's Disease
Chronic Inflammation: Introduction
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...