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Updated: Jun 14, 2026
08:12
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
Published on: July 15, 2015
Why not to use kidney grafts from elderly donors
M F Cassini1, A J Cologna, S Tucci
1Division of Urology, Department of Surgery and Anatomy, Ribeiro Preto Medical School, University of São Paulo, São Paulo, Brazil. marcelo.cassini@globo.com
Transplantation Proceedings
|March 23, 2010
Summary
Donor age significantly impacts kidney transplant success. Kidneys from donors over 40 years old result in shorter graft survival, increasing repeat transplants and mortality risks.
Area of Science:
- Nephrology
- Transplantation immunology
Background:
- Kidney transplantation is the optimal renal replacement therapy.
- Organ shortages and long waiting lists necessitate strategies to increase donor organ supply.
- Utilizing expanded donor criteria is one such strategy.
Purpose of the Study:
- To assess the influence of donor age on cadaver kidney graft survival.
Main Methods:
- Retrospective review of medical records for 454 kidney transplant recipients.
- Data collected from April 1987 to December 2003.
- Analysis focused on donor age, HLA matching, and cold ischemia time.
Main Results:
- Donor age significantly affected kidney transplant survival (P = .005).
- Grafts from donors aged 16-40 years had longer mean survival (143.30 months) compared to those from donors >40 years (66.46 months).
- HLA matching and cold ischemia time did not significantly impact survival.
Conclusions:
- Cadaver kidney donors older than 40 years are associated with significantly reduced graft survival.
- This negatively impacts recipients by increasing waiting list returns, repeat transplants, mortality, and healthcare costs.
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