Related Experiment Video
Updated: Jun 14, 2026
07:38
Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Induction with basiliximab in renal transplantation.
1Renal Transplantation Unit, Hospitais da Universidade de Coimbra, Coimbra, Portugal. franciscodina@gmail.com
Transplantation Proceedings
|March 23, 2010
Summary
Basiliximab induction therapy in renal transplantation significantly reduced acute rejection episodes. This approach did not increase infectious complications or impact patient and graft survival rates.
Area of Science:
- Nephrology
- Immunology
- Transplantation Medicine
Background:
- Monoclonal antibodies are used for induction therapy in renal transplantation.
- This therapy has been linked to reduced acute rejection rates.
- Impact on graft and patient survival is a key consideration.
Purpose of the Study:
- To assess the efficacy of basiliximab induction protocols in renal transplants.
- Evaluate rates of acute rejection episodes (ARE) and delayed graft function (DGF).
- Analyze infectious complications, patient, and graft survival within 6 months post-transplant.
Main Methods:
- Retrospective analysis of renal transplants (2000-2008).
- Compared recipients with (Group 1) and without (Group 2) basiliximab induction.
- Standard immunosuppression: cyclosporine, mycophenolate mofetil/mycophenolic acid, corticosteroids.
Main Results:
- 52 recipients in Group 1, 189 in Group 2.
- Group 1 showed significantly lower ARE rates (7.8% vs. 27.8%, P = .001).
- DGF and infectious complication rates were similar; no significant difference in graft/patient survival.
Conclusions:
- Basiliximab induction is associated with reduced ARE in renal transplants.
- This benefit was observed despite fewer HLA matches and longer dialysis time.
- Basiliximab did not increase infectious complications.
Related Concept Videos
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...