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Related Concept Videos

Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:

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Related Experiment Video

Updated: Jun 14, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Colorectal cancer.

David Cunningham1, Wendy Atkin, Heinz-Josef Lenz

  • 1Gastrointestinal Unit, Royal Marsden Hospital National Health Service Foundation Trust, London and Surrey, UK. David.cunningham@rmh.nhs.uk

Lancet (London, England)
|March 23, 2010
PubMed
Summary
This summary is machine-generated.

Significant advancements in colorectal cancer care include improved screening, surgical techniques, and chemotherapy regimens. Ongoing research focuses on genetic understanding and targeted therapies to further enhance patient survival and treatment efficacy.

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A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

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Last Updated: Jun 14, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Area of Science:

  • Oncology
  • Gastroenterology
  • Cancer Research

Background:

  • Colorectal cancer (CRC) management has seen considerable progress over the last decade.
  • Enhanced understanding of CRC genetics aids in identifying at-risk populations.
  • Advances in screening and surgical optimization have improved patient outcomes.

Purpose of the Study:

  • To review recent advancements in colorectal cancer diagnosis and treatment.
  • To highlight the impact of improved surgical techniques and adjuvant therapies.
  • To discuss the role of molecular markers and targeted treatments in optimizing patient care.

Main Methods:

  • Review of recent clinical studies and treatment guidelines for colorectal cancer.
  • Analysis of the impact of screening, surgery, and adjuvant chemotherapy on survival rates.
  • Evaluation of the role of preoperative chemoradiation and postoperative follow-up strategies.
  • Assessment of novel therapeutic approaches, including targeted treatments and molecular markers.

Main Results:

  • Screening and optimized surgery significantly improve 5- and 10-year survival rates for localized colorectal cancer.
  • Preoperative chemoradiation is crucial for high-risk rectal cancer patients, reducing local failure.
  • Adjuvant fluoropyrimidine and oxaliplatin-based chemotherapy enhance survival, particularly in stage III disease.
  • Targeted therapies integrated with chemotherapy show incremental survival gains in metastatic colorectal cancer.

Conclusions:

  • Multifaceted progress in screening, surgery, and chemotherapy has improved colorectal cancer outcomes.
  • Personalized treatment selection, guided by molecular markers and biomarkers, is essential for maximizing efficacy and minimizing toxicity.
  • Continued research into biomarker development is critical for advancing targeted therapies and improving patient survival in colorectal cancer.