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Updated: Jan 26, 2026

In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures
Published on: October 14, 2021
Axonal damage in leukodystrophies
1Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110-1093, USA. mars@neuro.wustl.edu
Abstract:
Recent advances in radioimaging and immunocytological techniques have enhanced investigations of neurometabolites and axons, giving rise to renewed interest in human white-matter disorders. A strong correlation between axonal loss and disability in some demyelination diseases (e.g., multiple sclerosis) led to several studies examining the mechanisms of axonal damage. We review the relationship between demyelination, axon loss, and neurologic progression, and the role of advanced neuroimaging in children with different types of leukodystrophies, i.e., X-linked adrenoleukodystrophy, metachromatic leukodysrtophy, Krabbe's disease, Pelizaeus-Merzbacher disease, and Alexander's disease.
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