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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Molecular Orbital Theory II03:51

Molecular Orbital Theory II

Molecular Orbital Energy Diagrams
Electron Orbital Model01:18

Electron Orbital Model

Orbitals are the areas outside of the atomic nucleus where electrons are most likely to reside. They are characterized by different energy levels, shapes, and three-dimensional orientations. The location of electrons is described most generally by a shell or principal energy level, then by a subshell within each shell, and finally, by individual orbitals found within the subshells.The first shell is closest to the nucleus, and it has only one subshell with a single spherical orbital called the...

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Related Experiment Video

Updated: Jun 14, 2026

Three-Dimensional Reconstruction of Orbital Fractures
08:18

Three-Dimensional Reconstruction of Orbital Fractures

Published on: May 16, 2025

[Orbital metastasis].

T Civit1, S Colnat-Coulbois, S Freppel

  • 1Département de neurochirurgie, hôpital Central, CHU de Nancy 29, avenue de Lattre-de-Tassigny, 54000 Nancy, France. t.civit@chu-nancy.fr

Neuro-Chirurgie
|March 23, 2010
PubMed
Summary
This summary is machine-generated.

Orbital metastases, rare tumors in adults, often originate from breast, lung, or prostate cancers. Radiotherapy remains the primary treatment for improving patient survival.

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Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

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Last Updated: Jun 14, 2026

Three-Dimensional Reconstruction of Orbital Fractures
08:18

Three-Dimensional Reconstruction of Orbital Fractures

Published on: May 16, 2025

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Area of Science:

  • Oncology
  • Ophthalmology
  • Radiology

Background:

  • Orbital metastases represent a rare but significant clinical challenge, accounting for approximately 4% of all adult orbital tumors.
  • These secondary tumors predominantly affect individuals around 60 years of age, with primary sites frequently identified in the breast, lung, or prostate.
  • Clinical presentation commonly includes proptosis, often accompanied by visual impairment, pain, and ptosis, necessitating prompt diagnosis and management.

Purpose of the Study:

  • To review the epidemiology, clinical presentation, diagnostic imaging features, pathological characteristics, and treatment of orbital metastases.
  • To highlight the diagnostic clues and current management strategies for this uncommon oncological condition.

Main Methods:

  • Systematic review of literature concerning orbital metastases.
  • Analysis of clinical, imaging, and pathological data from reported cases.
  • Evaluation of treatment outcomes, focusing on radiotherapy efficacy.

Main Results:

  • The most frequent primary tumors metastasizing to the orbit are breast (40%), lung (11%), and prostate (8%) carcinomas.
  • Enhanced extraconal tumors exhibiting osteolysis on imaging are suggestive of metastatic disease.
  • Pathological examination reveals no distinguishing features between the metastasis and the primary tumor.

Conclusions:

  • Orbital metastases, while uncommon, require a high index of suspicion, particularly in older adults with a history of common primary cancers.
  • Radiotherapy continues to be the gold standard treatment, offering the best survival outcomes for patients with orbital metastases.