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Gross Anatomy of Bone

Gross Anatomy of Bone

The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...

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Related Experiment Video

Updated: Jun 14, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

[Aneurysmatic bone cyst coexisting with osteosarcoma. Radiopathologic discussion].

A Bello Báez¹, M A López Pino, D Azorín Cuadrillero

¹Servicio de Radiodiagnóstico Hospital Universitario Nuestra Señora de la Candelaria, Tenerife, España. adanbellobaez@gmail.com

|March 23, 2010

Summary

Aneurysmal bone cysts are benign lesions, but this case shows a low-grade osteosarcoma mimicking their appearance. This highlights the challenge in diagnosing bone tumors and their potential for malignant transformation.

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Last Updated: Jun 14, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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Published on: September 9, 2020

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Area of Science:

Orthopedic Oncology
Skeletal Radiology
Pathology

Background:

Aneurysmal bone cysts (ABCs) are benign, idiopathic bone lesions.
Their etiology is debated, with theories including reaction to trauma or other bone tumors.
Malignant transformation of ABCs remains controversial.

Observation:

This study presents a rare case of low-grade osteosarcoma.
The osteosarcoma exhibited radiographic progression mimicking an aneurysmal bone cyst.
Diagnostic imaging alone was insufficient to differentiate the two conditions.

Findings:

Low-grade osteosarcoma can present with imaging characteristics indistinguishable from aneurysmal bone cysts.
Radiologic features alone may not reliably exclude malignancy in suspected ABCs.
The differential diagnosis for bone lesions requires careful consideration of imaging and clinical data.

Implications:

This case underscores the importance of considering malignant transformation in the differential diagnosis of aneurysmal bone cysts.
It highlights potential diagnostic challenges in distinguishing benign from malignant bone lesions based on imaging.
Further investigation and potentially biopsy are crucial for definitive diagnosis and appropriate patient management.