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Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

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Related Experiment Video

Updated: Jun 14, 2026

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

WRKY transcription factors.

Paul J Rushton1, Imre E Somssich, Patricia Ringler

  • 1Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA.

Trends in Plant Science
|March 23, 2010
PubMed
Summary

WRKY transcription factors regulate plant processes by acting as activators or repressors. These versatile proteins interact with partners to control diverse plant functions, showcasing complex regulatory networks.

Area of Science:

  • Plant Molecular Biology
  • Plant Physiology
  • Gene Regulation

Background:

  • WRKY transcription factors are a large family of plant transcriptional regulators.
  • They are integral components of signaling networks controlling numerous plant processes.
  • Recent research has significantly advanced our understanding of WRKY functions.

Purpose of the Study:

  • To review recent significant progress in WRKY transcription factor research.
  • To highlight the dual role of WRKY proteins as activators and repressors.
  • To explore the diverse protein interactions and regulatory mechanisms involving WRKYs.

Main Methods:

  • Literature review of recent scientific findings on WRKY transcription factors.
  • Analysis of studies detailing WRKY protein functions and interactions.

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High-throughput Purification of Affinity-tagged Recombinant Proteins

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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

Related Experiment Videos

Last Updated: Jun 14, 2026

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

High-throughput Purification of Affinity-tagged Recombinant Proteins
07:44

High-throughput Purification of Affinity-tagged Recombinant Proteins

Published on: August 26, 2012

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

  • Examination of research on WRKY gene autoregulation and cross-regulation.

    • Main Results:

    • WRKY proteins function as both activators and repressors, involved in repression and de-repression.
    • Individual WRKY factors can regulate multiple, seemingly unrelated plant processes.
    • WRKYs interact with diverse partners, including MAP kinases, 14-3-3 proteins, and histone deacetylases.
    • WRKY genes show extensive autoregulation and cross-regulation, creating dynamic, redundant networks.

    Conclusions:

    • WRKY transcription factors are key regulators with multifaceted roles in plant development and stress responses.
    • Their complex interactions and regulatory mechanisms contribute to sophisticated control of plant processes.
    • Understanding WRKY networks is crucial for deciphering plant signaling and transcriptional reprogramming.