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Published on: September 15, 2017
Translation control: a multifaceted regulator of inflammatory response
Barsanjit Mazumder1, Xiaoxia Li, Sailen Barik
1Department of Biology, Geology and Environmental Science, Center for Gene Regulation in Health and Disease, College of Science, Cleveland State University, Cleveland, OH 44115, USA. b.mazumder@csuohio.edu
Journal of Immunology (Baltimore, Md. : 1950)
|March 23, 2010
Summary
Innate immunity protects vertebrates but can cause harmful inflammation. Cells use translational silencing to control this, offering a potential new drug target for inflammatory diseases.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- The innate immune response is vital for vertebrate defense against pathogens.
- Uncontrolled inflammation can lead to severe tissue damage and various diseases.
- Cells possess mechanisms to terminate inflammatory processes before they become detrimental.
Purpose of the Study:
- To review and highlight the primary cellular mechanism for terminating inflammatory responses.
- To explore the role of translational silencing in regulating inflammatory gene expression.
- To identify potential therapeutic strategies based on enhancing inflammatory control.
Main Methods:
- Review of recent scientific literature on innate immunity and inflammation control.
- Analysis of cellular mechanisms involved in regulating mRNA translation.
- Examination of cis-acting RNA structures and regulatory proteins in inflammation.
Main Results:
- Translational silencing is identified as the dominant mechanism for shutting off inflammatory responses.
- Specific regulatory proteins bind to RNA structures in untranslated regions of inflammatory mRNAs.
- This process selectively inhibits the production of inflammatory proteins.
Conclusions:
- Translational silencing is a key cellular safeguard against excessive inflammation.
- Targeting and enhancing this silencing mechanism presents a novel pharmacological approach.
- This strategy could be used to prevent or treat inflammation-related disorders.
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