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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...

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Related Experiment Video

Updated: Jun 14, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Isolated pyuria in systemic lupus erythematosus.

S Appenzeller1, A Clark, C Pineau

  • 1Division of Clinical Immunology/Allergy, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.

Lupus
|March 23, 2010
PubMed
Summary

Isolated pyuria, defined as white blood cells in urine without infection, occurred in 13.6% of systemic lupus erythematosus patients. This finding may indicate active lupus, even without typical kidney involvement signs.

Related Experiment Videos

Last Updated: Jun 14, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

  • Nephrology
  • Rheumatology
  • Clinical Medicine

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease with potential multi-organ involvement.
  • Pyuria, the presence of white blood cells in urine, can indicate infection or inflammation.
  • Isolated pyuria in SLE patients, without signs of infection, requires further investigation.

Purpose of the Study:

  • To assess the prevalence of isolated pyuria in an unselected SLE patient cohort.
  • To identify demographic and clinical factors associated with isolated pyuria in SLE.
  • To explore the potential link between isolated pyuria and lupus disease activity.

Main Methods:

  • A cross-sectional study of 198 SLE patients from a lupus clinic.
  • Isolated pyuria defined as >10 WBC/HPF without bacteriuria, hematuria, proteinuria, or casts.
  • Univariate and multivariate logistic regression analyses were used to assess associations with clinical factors.

Main Results:

  • 13.6% (27/198) of SLE patients presented with isolated pyuria.
  • Patients with isolated pyuria were more likely to have prior American College of Rheumatology criteria for renal involvement (OR=2.55).
  • A trend towards higher non-renal SLE disease activity was observed in patients with isolated pyuria, though not statistically significant in adjusted analyses.

Conclusions:

  • Isolated pyuria is a notable finding in a significant subset of SLE patients.
  • While not definitive, isolated pyuria may correlate with underlying lupus activity, even in the absence of overt renal manifestations.
  • Further research is warranted to elucidate the precise mechanisms and clinical significance of isolated pyuria in SLE.