Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluid distribution and pulmonary dysfunction following burn shock.

S Shimazaki1, T Yukioka, H Matuda

  • 1Department of Traumatology and Critical Care Medicine, Kyorin University School of Medicine, Tokyo, Japan.

The Journal of Trauma
|May 1, 1991
PubMed
Summary

Hypertonic lactated saline (HLS) resuscitation in burn patients improved respiratory function compared to lactated Ringer's solution. HLS reduced respiratory index and plasma-to-interstitial fluid volume ratio, potentially mitigating respiratory dysfunction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seasonal occurrence and development of three closely related Oligonychus species (Acari: Tetranychidae) and their associated natural enemies on fagaceous trees.

Experimental & applied acarology·2019
Same author

Nuclear resonant scattering measurements on (57)Fe by multichannel scaling with a 64-pixel silicon avalanche photodiode linear-array detector.

The Review of scientific instruments·2014
Same author

Follow-up of a self-resolving renal pseudoaneurysm using contrast-enhanced power Doppler ultrasonography.

Emergency medicine journal : EMJ·2009
Same author

Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial.

Journal of thrombosis and haemostasis : JTH·2006
Same author

Classification of Clostridium butyricum based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and pulsed-field gel electrophoresis.

Anaerobe·2006
Same author

The role of edaravone on the impairment of endothelial barrier function induced by acute oxidative stress in cultured human umbilical vein endothelial cell monolayer.

The Journal of trauma·2005

Area of Science:

  • Burn resuscitation
  • Critical care medicine
  • Physiology

Background:

  • Burn injuries cause significant fluid shifts and respiratory complications.
  • Fluid resuscitation strategies impact patient outcomes.
  • Understanding extracellular fluid distribution is crucial for managing burn patients.

Purpose of the Study:

  • To compare the effects of hypertonic lactated saline (HLS) versus isotonic sodium (iso-Na) resuscitation on respiratory function and body fluid changes in burn patients.
  • To investigate the relationship between extracellular fluid distribution and respiratory dysfunction post-burn.

Main Methods:

  • Prospective study of 46 burn patients.
  • Patients divided into HLS (n=17) and iso-Na (n=29) groups.
  • Measured respiratory index, extracellular fluid volume, and plasma to interstitial fluid volume ratio up to 7 days postburn.

Related Experiment Videos

Main Results:

  • HLS group showed a lower Respiratory Index and plasma volume to interstitial fluid volume (PV/ISFV) ratio between days 3-5 postburn compared to the iso-Na group.
  • Significant correlation between Respiratory Index and PV/ISFV ratio, indicating less respiratory dysfunction with HLS.
  • Nearly 50% of the iso-Na group required endotracheal intubation, versus fewer in the HLS group.

Conclusions:

  • Extracellular fluid distribution differs significantly between HLS and iso-Na resuscitation.
  • HLS resuscitation may ameliorate respiratory function due to less volume loading and a lower PV/ISFV ratio.
  • HLS may be a beneficial alternative for fluid resuscitation in severe burn patients to improve respiratory outcomes.