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Imiquimod 5% cream for the treatment of periocular Basal cell carcinoma
Rachel Camargo Carneiro1, Erick Marcet Santiago de Macedo, Suzana Matayoshi
1Department of Ophthalmology and Otorhinolaryngology, University of São Paulo School of Medicine, São Paulo, Brazil. rccarneiro@msn.com
Purpose:
The objective of this pilot study was to evaluate the efficacy and safety of 5% imiquimod cream in the treatment of periocular basal cell carcinoma (BCC) through the analysis of a case series.
Methods:
Eight subjects with primary nodular BCC of the eyelid were recruited. Treatment lasted 10 to 16 weeks. The average follow-up time was 11.7 months.
Results:
Of a total of 10 lesions, 80% resolved clinically and histologically and have remained asymptomatic since.
Conclusion:
Imiquimod cream 5% was shown to be an attractive alternative to surgical treatment of periocular BCC. Future studies with larger samples and longer follow-up periods are expected to provide more accurate information on the efficacy and safety of the drug.
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