IgA orbital plasmacytoma in multiple myeloma
Victoria J Hsu1, Madhu R Agarwal, Chien-Shing Chen
1Department of Ophthalmology, Loma Linda University Medical Center, Loma Linda, California 92354, USA.
Ophthalmic Plastic and Reconstructive Surgery
|March 23, 2010
Summary
This case study details orbital plasmacytoma in a multiple myeloma patient. Treatment involved surgery, radiation, and chemotherapy, leading to vision improvement.
Area of Science:
- Oncology
- Ophthalmology
Background:
- Multiple myeloma is a plasma cell malignancy.
- Orbital involvement is rare but can cause significant visual impairment.
Observation:
- A 48-year-old man with IgA lambda multiple myeloma presented with proptosis, diplopia, and decreased vision.
- Previous treatments included chemotherapy, radiation, and stem cell transplant.
Findings:
- Surgical debulking and orbital radiation led to improved vision and reduced disc edema.
- Tumor cells expressed CD138, consistent with plasma cell origin.
Implications:
- This case highlights the importance of considering orbital plasmacytoma in multiple myeloma patients with ocular symptoms.
- Further research into optimal management strategies for orbital plasmacytoma is warranted.
