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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Lupus nephritis: where are we now?
1Imperial College Kidney and Transplant Institute, Imperial College London, and West London Renal and Transplant Centre, Hammersmith Hospital, London, UK. l.lightstone@imperial.ac.uk
Current Opinion in Rheumatology
|March 23, 2010
Summary
Managing lupus nephritis (LN) involves diagnostic and therapeutic challenges. Emerging evidence supports personalized treatment strategies for LN, considering individual patient factors beyond disease severity.
Area of Science:
- Nephrology
- Immunology
- Rheumatology
Background:
- Lupus nephritis (LN) management presents significant diagnostic and therapeutic hurdles.
- Optimal induction and maintenance of remission remain challenging clinical issues.
Purpose of the Study:
- To review current challenges in lupus nephritis management.
- To discuss diagnosis and optimal therapy for induction and maintenance of response in LN.
Main Methods:
- Review of recent clinical trials and data in lupus nephritis.
- Analysis of treatment strategies including mycophenolate mofetil, rituximab, and tacrolimus.
- Examination of diagnostic criteria and outcome predictors.
Main Results:
- No second-line drug is currently licensed for induction of remission in LN.
- Mycophenolate mofetil shows subgroup superiority; tacrolimus emerges as a potential treatment.
- Steroid-sparing regimens are increasingly feasible with mycophenolate mofetil and rituximab.
Conclusions:
- Despite trial setbacks, personalized treatment approaches for LN are expanding.
- Treatment tailoring considers nephritis class, severity, ethnicity, reproductive desires, and outcome predictors.
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