Related Experiment Video
Updated: Jun 14, 2026
03:37
Self-Administration of Drugs in Mouse Models of Feeding and Obesity
Published on: June 8, 2021
Hyperprolactinaemia - a risperidone side-effect
Tanja Grahovac1, Klementina Ruzić, Paola Medved
1University Psychiatric Clinic Rijeka, Clinical Hospital Centre Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
Psychiatria Danubina
|March 23, 2010
Summary
Risperidone effectively treated psychotic depression but caused hyperprolactinemia. Gradual dose reduction normalized prolactin levels, managing this side effect.
Area of Science:
- Psychiatry
- Endocrinology
- Pharmacology
Background:
- Psychotic depression is a severe mental health condition requiring effective treatment.
- Antipsychotic medications are used to manage symptoms of psychotic depression.
- Risperidone is an atypical antipsychotic used in treating various psychiatric disorders.
Observation:
- A patient with psychotic depression experienced symptom remission with risperidone treatment.
- Long-term risperidone use led to significantly elevated prolactin levels (hyperprolactinemia).
- Hyperprolactinemia is a known side effect associated with risperidone use.
Findings:
- The patient presented with "bleeding" attributed to drug-induced hyperprolactinemia.
- Hormonal tests confirmed high prolactin levels (2567.0 mIJ/L) during risperidone therapy.
- A gradual reduction in risperidone dosage resulted in normalized prolactin levels within one month.
Implications:
- This case highlights the importance of monitoring prolactin levels in patients on risperidone.
- Managing drug-induced hyperprolactinemia requires careful dose adjustment or alternative treatments.
- Understanding and addressing medication side effects is crucial for long-term patient well-being and treatment adherence.
Related Concept Videos
01:24Parkinson's Disease: Treatment
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
01:21Antipsychotic Drugs: Therapeutic Uses and Side Effects
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
01:28Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
01:21Antipsychotic Drugs: Typical and Atypical Agents
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
01:21Skeletal Muscle Relaxants: Adverse Effects
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...