Imaging informatics: challenges in multi-site imaging trials

Area of Science:

• Medical imaging research
• Clinical informatics
• Biomedical data science

Background:

• Multi-site imaging research presents unique challenges distinct from clinical imaging systems.
• Existing medical imaging standards (DICOM, HL7, IHE) primarily address results reporting and standardization, not collaborative research needs.
• Tools for multi-site imaging collaboration and data mining remain underdeveloped.

Purpose of the Study:

• To identify existing clinical interoperability methods applicable to multi-site imaging research.
• To harmonize the clinical and research imaging domains.
• To pinpoint gaps in current interoperability solutions for collaborative imaging research.

Main Methods:

• Detailed examination of a specific multi-site imaging trial's approach.
• Identification of current deficiencies and workarounds implemented within the trial.
• Review of existing literature and initiatives addressing multi-site imaging challenges.

Main Results:

• Clinical interoperability standards offer partial solutions but significant gaps exist for research collaboration.
• Specific multi-site trial encountered challenges in data sharing and harmonization.
• Workarounds were developed to address immediate needs, highlighting areas for improvement.

Conclusions:

• Existing clinical interoperability frameworks need enhancement to fully support multi-site imaging research.
• Further development of tools for data mining and collaboration is crucial for advancing multi-site imaging studies.
• Bridging the gap between clinical and research imaging practices requires targeted solutions.