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Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 14, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
09:16

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Published on: September 1, 2019

Lineage-specific transcription factor aberrations in AML.

Beatrice U Mueller1, Thomas Pabst

  • 1Department of Internal Medicine, University Hospital, 3010, Bern, Switzerland. beatrice.mueller@insel.ch

Cancer Treatment and Research
|March 23, 2010
PubMed
Summary

Transcription factors regulate cell differentiation, and their aberrations are crucial in acute myeloid leukemia (AML). This review covers recent findings on these transcription factor errors in AML patients.

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Area of Science:

  • Molecular Biology
  • Hematology
  • Oncology

Background:

  • Transcription factors are critical for hematopoietic stem cell differentiation into specific lineages.
  • Impaired terminal differentiation is a primary cause of acute leukemias.
  • Transcription factor roles in differentiation are relevant to normal development and cancer across tissues.

Purpose of the Study:

  • To review recent findings on aberrations in lineage-restricted transcription factors in acute myeloid leukemia (AML).

Main Methods:

  • Literature review of recent findings on transcription factor aberrations in AML.
  • Analysis of the role of transcription factors in hematopoietic lineage commitment and differentiation.

Main Results:

  • Aberrations in transcription factors are frequently observed in acute myeloid leukemia (AML) patients.
  • Lineage-restricted transcription factors are key players in hematopoietic differentiation and AML pathogenesis.

Conclusions:

  • Understanding transcription factor aberrations in AML is crucial for insights into disease mechanisms.
  • These findings highlight the potential of targeting transcription factors for therapeutic strategies in AML.