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Human infection with Salmonella dublin.

F C Fang1, J Fierer

  • 1Department of Medicine, University of California, San Diego Medical Center.

Medicine
|May 1, 1991
PubMed
Summary

Salmonella dublin infections in humans are rare but severe, often linked to unpasteurized dairy or raw calf liver. These infections can lead to high rates of bacteremia and mortality, especially in those with chronic illnesses.

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Epidemiology

Background:

  • Salmonella dublin is a specific serotype of Salmonella.
  • Non-typhoidal Salmonellae are a significant cause of foodborne illness.
  • Understanding the epidemiology and clinical presentation of specific Salmonella serotypes is crucial for public health.

Observation:

  • A 12-year study identified 27 human Salmonella dublin infections at UC San Diego-affiliated hospitals.
  • Key risk factors included consumption of unpasteurized dairy products and nutritional therapy with raw calf liver extracts.
  • Most infected patients had pre-existing chronic diseases.

Findings:

  • Salmonella dublin infections exhibited a high incidence of bacteremia (91%), metastatic infections (30%), and mortality (26%).
  • These outcomes were comparable to Salmonella choleraesuis and significantly higher than other non-typhoidal Salmonellae.
  • A potential plasmid-encoded virulence factor common to S. dublin and S. choleraesuis may explain the severe disease pattern.

Implications:

  • Clinicians should consider Salmonella dublin in patients with severe infections, particularly those with relevant exposure history.
  • Public health interventions should focus on preventing consumption of contaminated unpasteurized dairy and raw animal products.
  • Further research into plasmid-mediated virulence factors could inform novel therapeutic strategies against severe Salmonella infections.

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